Mixed Regulatory Background
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 7 of 16 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression with unknown coherence. Hub genes include: CLOCK (circadian rhythm master regulator), TRAPPC8 (vesicle trafficking/TRAPP complex), NSD2 (histone H3K36 methyltransferase), MAPK1/ERK2 (MAPK signaling), PDS5B (cohesin), AGO3 (Argonaute/miRNA silencing), WASHC4 (actin/endosome), IL6R (cytokine receptor), SMG7 (nonsense-mediated decay), KDM5C (histone demethylase), ATG14 (autophagy), TAF2 (transcription). CLOCK is notable as a circadian regulator, and AGO3 parallels AGO1 in M78 (neighbor), suggesting some RNA regulatory overlap. However, the module is highly heterogeneous with no single dominant program. The presence of CLOCK alongside epigenetic regulators (NSD2, KDM5C), signaling (MAPK1, IL6R), and autophagy (ATG14) does not resolve into a coherent biological program. This is another weakly defined background/housekeeping module consistent with the neighborhood.
Genes
Most correlated modules
- Mixed Regulatory Background · correlation 0.90
- Mixed Regulatory Background · correlation 0.89
- Mixed Regulatory Background · correlation 0.88
- Autophagy & Proteostasis · correlation 0.81
- ARF-mediated Trafficking · correlation 0.80
- Stress Kinase Signaling · correlation 0.79
- Mixed Regulatory · correlation 0.75
- DNA Damage Response · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.