Epigenetic Silencing
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 21 genes have a known function matching the annotation |
Why this annotation
EZH1 (PRC2 complex histone H3K27 methyltransferase) and HDAC1 (histone deacetylase 1) are major epigenetic silencing factors. MPHOSPH8 (M-phase phosphoprotein 8, part of HUSH complex for heterochromatin). CYTH4 (cytohesin-4, ARF GEF expressed in immune cells). DERL3 (derlin-3, ER-associated protein degradation). The module is anchored by chromatin/epigenetic silencing machinery (EZH1, HDAC1, MPHOSPH8) suggesting a Polycomb/HDAC-mediated gene repression program. All genes show weak membership and uniform expression, indicating a loosely defined housekeeping epigenetic program.
Genes
Most correlated modules
- IFN Receptor Signaling · correlation 0.86
- Transcriptional Regulation · correlation 0.84
- Immune Cell Migration · correlation 0.83
- Endosomal Trafficking · correlation 0.82
- Transcriptional Coactivation · correlation 0.82
- Monocyte Chemotaxis · correlation 0.81
- Mixed Regulatory · correlation 0.79
- DNA Repair & Chromatin · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.