UC Inflammatory Activation
Gene co-expression module in Pericytes
| Category | Inflammatory |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
This core module is strongly upregulated in UC inflammation (delta_inflammation_UC=0.527, significant). Hub genes include CD200 (immunomodulatory glycoprotein expressed on pericytes to suppress myeloid activation), CSF2RB (cytokine receptor), HLA-DQA1 (antigen presentation), BDKRB2 (bradykinin receptor, vascular inflammation mediator), STAB1 (scavenger/anti-inflammatory receptor), and RGCC (apoptosis/cell cycle regulator). Pericyte identity anchors MEOX1 and TSHZ2 confirm this is a pericyte-intrinsic program. Together these genes represent an immunomodulatory inflammatory activation state in pericytes specific to UC.
Genes
BDKRB2, CD200, CSF2RB, DUSP23, HLA-DQA1, MEOX1, NR5A2, PCDH17, RGCC, STAB1, TSHZ2, ZNF385D
Most correlated modules
- Basement Membrane Maintenance · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.