Basement Membrane Maintenance
Gene co-expression module in Pericytes
| Category | ECM production |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes HSPG2 (perlecan, the major heparan sulfate proteoglycan of the vascular basement membrane), VWF (von Willebrand factor, expressed in pericytes and endothelium), CALCRL (CGRP/adrenomedullin receptor, key vasoactive peptide signaling in pericytes), RAPGEF4 (Epac2, cAMP-Rap1 signaling), and DYSF (dysferlin, membrane repair/fusion) collectively define a basement membrane maintenance and vasoactive signaling program. GRB10 links to IGF/insulin receptor signaling. RFLNB (refilin B) regulates actin filament organization. This module represents pericyte-specific basement membrane production and vasoactive peptide responsiveness.
Genes
CALCRL, DYSF, EXOC3L1, FAM167B, GRB10, HSPG2, PPM1F, RAPGEF4, RFLNB, VWF
Most correlated modules
- Angiogenic Receptor Signaling · correlation 0.98
- YAP/TAZ Mechanosensing · correlation 0.97
- Vascular Permeability · correlation 0.96
- BMP-SMAD Signaling · correlation 0.96
- Rho GTPase Signaling · correlation 0.95
- Vascular Junction Adhesion · correlation 0.94
- Vascular Pericyte Identity · correlation 0.94
- Pericyte Contractile Tone · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.