RGCC — Regulator of cell cycle

RGCC belongs to a gene co-expression module in 15 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

RGCC's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Activation/Migration BCR/AP1/NFKb pathway	AHNAK, DUSP10, DUSP8, GGA1, GPR183, GPR65, IDS, KLF6 +11 more	View in SCUBA
CD4⁺ T cells	Glucocorticoid Immunoregulation Immune regulation	AHNAK, BTG1, CRIP1, GGNBP2, IDS, INSIG1, IRS2, JUND +11 more	View in SCUBA
CD8⁺ T cells	Immediate Early Response Stress	ARRDC3, ATF3, CLK1, EIF4A2, EIF5, GADD45B, IER5, JUN +6 more	View in SCUBA
Endothelial	VEGF Tip Cell Signaling Endothelial cell development	ADAMTS5, BDKRB2, CA2, CBLB, CCND1, DGKD, ESM1, GABRD +7 more	View in SCUBA
Fibroblasts	Cytokine Inflammatory Response Inflammatory	CXCL2, DNAJB4, GFPT2, HES4, MAP3K8, MMP19, RASL11A, RND3 +4 more	View in SCUBA
Gamma-delta T cells	TGF-beta Response Immune regulation	ADGRE5, CD83, CHMP1B, CHST7, DDIT3, DNAAF2, EHD4, FAM43A +15 more
Glial cells	Glial Quiescence State Development	AATK, CDKN1C, FADS3, PPP1R10, RSRP1, SLC38A2, SOX2, SRSF5	View in SCUBA
Goblet cells	NF-kB Inflammatory Signaling chromatin regulation & transcription	CD69, CXCR4, DDX21, DUSP2, FOSL2, IRF1, NFKB2, REL +5 more	View in SCUBA
Innate lymphoid cells	NF-κB Inflammatory Activation Inflammation	AHI1, CD83, FAM107B, FKBP2, GADD45A, HES4, KDM6B, MRPS36 +7 more	View in SCUBA
Macrophages	Inflammatory Monocyte Activation Inflammatory	ANPEP, AQP9, CD300E, CD82, CLEC5A, CXXC5, DDX60L, DHRS9 +25 more	View in SCUBA
Monocytes	Integrin-mediated Migration Migration & adhesion	DNAAF1, EIF4E, ITGA5, ITGB8, LMNA, MSC, NRIP3, PHLDA1 +7 more	View in SCUBA
Mucosal-associated invariant T cell	Stress-Induced Growth Arrest Stress	CDKN1A, GNA15, KDM6B, KLF10, MMP9, MYADM, NOCT, NR4A3 +8 more
Neutrophils	Immature Neutrophil Granule Developmental	BPI, CCDC85B, CD24, CEACAM8, CPNE3, OLFM4, RETN, SVIP
Pericytes	UC Inflammatory Activation Inflammatory	BDKRB2, CD200, CSF2RB, DUSP23, HLA-DQA1, MEOX1, NR5A2, PCDH17 +3 more	View in SCUBA
Smooth muscle cells	Actomyosin Regulation Contractility	ARID5A, ASAH1, CAP2, COX6A2, DMTN, GABRA4, HAPLN2, NAPA +6 more	View in SCUBA

About the gene

Synonyms	bA157L14.2, C13orf15, RGC-32, RGC32
Chromosome	13: 41457550-41470871
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins
Biological process	Cell cycle

Function

Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.