MEOX1 — Mesenchyme homeobox 1
MEOX1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MEOX1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Endothelial Activation Inflammation | ANXA6, CNIH1, COTL1, DEGS1, DHRS7, F2R, FKBP10, FSTL1 +8 more | View in SCUBA |
| Pericytes | UC Inflammatory Activation Inflammatory | BDKRB2, CD200, CSF2RB, DUSP23, HLA-DQA1, NR5A2, PCDH17, RGCC +3 more | View in SCUBA |
About the gene
| Synonyms | MOX1 |
|---|---|
| Chromosome | 17: 43640389-43661922 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, Developmental protein, DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.