hnRNP RNA Processing
Gene co-expression module in Plasma cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes include TIMM8B (mitochondrial inner membrane translocase), PSMA4 (proteasome alpha subunit), HNRNPR/HNRNPA3/HNRNPM/HNRNPD (heterogeneous nuclear ribonucleoproteins — pre-mRNA splicing/processing), LSM7 (Sm-like protein, splicing), CBX3 (HP1gamma, chromatin), UQCRQ (Complex III), MRPS34/MRPL14/MRPL57/MRPL41 (mitoribosome subunits), UFD1 (ubiquitin fusion degradation), DDX39A (RNA helicase, mRNA export), SRM (spermidine synthase). This is a mixed module combining hnRNP-mediated RNA processing with mitoribosome/OxPhos components. The hnRNP cluster is the dominant RNA processing program; the mitoribosomal genes link it to neighbors M2 and M28. Classified as RNA processing given the plurality of hnRNP hub genes.
Genes
Most correlated modules
- Chaperonin Protein Folding · correlation 0.98
- Spliceosome snRNP Assembly · correlation 0.98
- RNA Splicing & Glycolysis · correlation 0.97
- Proteasome Activity · correlation 0.97
- OxPhos & Proteasome · correlation 0.97
- Oxidative Stress Response · correlation 0.97
- Mitochondrial Respiration · correlation 0.97
- Ribosome Biogenesis · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.