Ribosome Biogenesis
Gene co-expression module in Plasma cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 14 of 20 genes have a known function matching the annotation |
Why this annotation
DKC1 (dyskerin, pseudouridylation of rRNA, ribosome biogenesis), IMP4 (U3 snoRNP, rRNA processing), BUD23 (18S rRNA methyltransferase), DDX46 (spliceosome/rRNA), MRPL32 and MRPL11 (mitochondrial ribosomal proteins), CLPP (mitochondrial matrix protease), PSMG1 (proteasome assembly chaperone), POLR2F (RNA Pol II subunit), TXNL4A (U5 snRNP/splicing), SRSF10 (splicing factor), SUPT16H (FACT histone chaperone), CBX5/HP1α (heterochromatin, 7.9x), LMNB1 (nuclear lamina, 15.6x), BCL2L12 (anti-apoptotic). The module combines ribosome biogenesis with nuclear lamina/heterochromatin organization. LMNB1 and CBX5 enrichment in plasmablasts is striking. This reflects the ribosome biogenesis and nuclear organization program supporting plasmablast expansion.
Genes
Most correlated modules
- RNA Splicing & Glycolysis · correlation 0.97
- Spliceosome snRNP Assembly · correlation 0.97
- Proteasome Activity · correlation 0.97
- hnRNP RNA Processing · correlation 0.97
- Mitochondrial Biogenesis · correlation 0.96
- Chaperonin Protein Folding · correlation 0.96
- Oxidative Stress Response · correlation 0.96
- Glycolytic Reprogramming · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.