Chaperonin Protein Folding
Gene co-expression module in Plasma cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
The module combines chaperonin-mediated protein folding (CCT3, CCT5, PPIA/cyclophilin A) with chromatin/nuclear regulatory proteins (SET, ANP32A, XRCC5/Ku80, NAA50, ANAPC5). Moderate coherence with several weak members reflects this mixed composition. The dominant functional theme across the highest-PageRank genes is protein folding and proteostasis support, consistent with the high secretory demand of plasmablasts. Neighbor to M78 (OxPhos) and M77 (ribosome biogenesis), all part of a plasmablast activation program. MRPL37 adds a mitoribosomal component linking to M78.
Genes
Most correlated modules
- RNA Splicing & Glycolysis · correlation 0.98
- hnRNP RNA Processing · correlation 0.98
- Actin Cytoskeletal Dynamics · correlation 0.98
- Proteasome Activity · correlation 0.98
- Spliceosome snRNP Assembly · correlation 0.97
- Glycolytic Reprogramming · correlation 0.97
- Ribosome Biogenesis · correlation 0.97
- Ribosome Biogenesis · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.