RNA Splicing & Glycolysis
Gene co-expression module in Plasma cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes include ENO1/PKM (glycolysis), SNRPD2/SNRPB/SNRPD3 (snRNP spliceosome), ILF2/YBX1/SERBP1/RBM8A (RNA-binding/processing), RAN (nuclear-cytoplasmic transport), PA2G4 (ribosome biogenesis), EXOSC8 (RNA exosome), NHP2 (H/ACA snoRNP). This is a tightly co-regulated RNA processing and glycolytic program highly enriched in plasmablasts. The combination of splicing factors and glycolytic enzymes reflects the intense biosynthetic activity of plasmablasts. Neighbor modules M2/M10 share the plasmablast metabolic theme, with M10 also containing hnRNP splicing factors, supporting this RNA processing identity.
Genes
Most correlated modules
- Spliceosome snRNP Assembly · correlation 0.98
- Proteasome Activity · correlation 0.98
- Chaperonin Protein Folding · correlation 0.98
- Glycolytic Reprogramming · correlation 0.98
- Actin Cytoskeletal Dynamics · correlation 0.97
- hnRNP RNA Processing · correlation 0.97
- Mitochondrial Respiration · correlation 0.97
- Ribosome Biogenesis · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.