Oxidative Stress Response
Gene co-expression module in Plasma cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes: TKT (transketolase, pentose phosphate pathway), C1QBP (mitochondrial ribosome assembly factor, complement C1q binding, stress response), SNF8 (ESCRT-II complex, endosomal sorting), PDCD5 (programmed cell death 5, apoptosis sensitizer), TIMM13 (mitochondrial import TIM complex), NUDT1/MTH1 (8-oxo-dGTPase, oxidative nucleotide sanitization — extremely high plasmablast enrichment at 23.4x), GADD45GIP1 (GADD45 gamma interacting protein, stress/growth arrest), NDUFS7 (Complex I), PPP1R14B (PP1 regulatory subunit). The module combines oxidative stress response (NUDT1, GADD45GIP1), mitochondrial integrity (TIMM13, NDUFS7, C1QBP), metabolic reprogramming (TKT), and apoptosis sensitization (PDCD5). The extreme enrichment of NUDT1 in plasmablasts and the stress-response genes suggest this reflects oxidative/metabolic stress in highly active plasmablasts. Significantly upregulated with inflammation.
Genes
Most correlated modules
- Glycolytic Reprogramming · correlation 0.98
- hnRNP RNA Processing · correlation 0.97
- RNA Splicing & Glycolysis · correlation 0.97
- Proteasome Activity · correlation 0.97
- Chaperonin Protein Folding · correlation 0.96
- Spliceosome snRNP Assembly · correlation 0.96
- OxPhos & Proteasome · correlation 0.96
- Ribosome Biogenesis · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.