Housekeeping Mixed
Gene co-expression module in Plasma cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 13 of 20 genes have a known function matching the annotation |
Why this annotation
This weakly coherent module contains a heterogeneous mix of housekeeping and metabolic genes. NTHL1 (base excision repair DNA glycosylase), RAD23B (nucleotide excision repair shuttle factor), and ITPA (inosine triphosphate pyrophosphatase, nucleotide pool sanitization) suggest DNA/nucleotide quality control. PSME3 (proteasome PA28 activator), OTUB1 (deubiquitinase), and PFDN1 (prefoldin chaperone) indicate protein quality control. TOMM40 (mitochondrial outer membrane translocase) and MRPL28 (mitoribosomal protein) add mitochondrial context. EXOSC7 (RNA exosome), RTCB (RNA ligase), SRSF1 (splicing factor), and RPP30 (RNase P) reflect RNA processing. ALG3 (N-glycosylation) and ZDHHC12 (palmitoylation) add ER/lipid modification. The module likely reflects general cellular housekeeping in proliferating plasmablasts. Weak coherence and mostly weak membership confirm a loosely co-regulated housekeeping program. Significant inflammation upregulation may reflect increased plasmablast proliferative activity.
Genes
Most correlated modules
- hnRNP RNA Processing · correlation 0.96
- Chaperonin Protein Folding · correlation 0.96
- Proteasome Activity · correlation 0.96
- RNA Splicing Processing · correlation 0.96
- Actin Cytoskeletal Dynamics · correlation 0.96
- Glycolytic Reprogramming · correlation 0.96
- Ribosome Biogenesis · correlation 0.96
- Mitochondrial Biogenesis · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.