Actin Cytoskeletal Dynamics
Gene co-expression module in Plasma cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by actin cytoskeletal regulators: ARHGDIB (Rho GDI beta, regulates Rho GTPases), MSN (moesin, ERM family linking actin to membrane), CFL1 (cofilin-1, actin depolymerization), ARPC5 (Arp2/3 complex subunit, actin branching), ACTR3 (Arp3, actin branching nucleation), TPM3 (tropomyosin 3, actin filament stabilization), CAPZB (actin capping protein beta), LSP1 (lymphocyte-specific actin-binding protein). YWHAB (14-3-3 beta) scaffolds signaling to cytoskeletal regulators. XRCC6 and PARP1 add DNA repair, and ATP5F1A/NDUFB10/TPI1 add metabolic components. The actin dynamics program is the clearest and most coherent theme, consistent with plasmablast migration and morphological changes during gut homing. Neighbor M50 also contains ARPC2/3, and M88 contains ARPC1B/4, confirming Arp2/3-driven actin remodeling as a shared neighborhood theme.
Genes
Most correlated modules
- Chaperonin Protein Folding · correlation 0.98
- RNA Splicing & Glycolysis · correlation 0.97
- Proteasome Activity · correlation 0.97
- Glycolytic Reprogramming · correlation 0.97
- Mitochondrial Respiration · correlation 0.97
- hnRNP RNA Processing · correlation 0.96
- Spliceosome snRNP Assembly · correlation 0.96
- Housekeeping Mixed · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.