Glycolytic Reprogramming
Gene co-expression module in Plasma cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include LDHA (lactate dehydrogenase A, glycolysis/Warburg), PGAM1 (phosphoglycerate mutase, glycolysis), TALDO1 (transaldolase, pentose phosphate pathway), CYC1 (cytochrome c1, Complex III), UQCRFS1 (Complex III Rieske subunit), TUFM (mitochondrial translation elongation factor), STOML2 (mitochondrial stomatin-like), SLIRP (mitochondrial RNA binding), MRPL22 (mitochondrial ribosome large subunit), BOLA3 (iron-sulfur cluster assembly). FABP5 (fatty acid binding protein 5, 12.7x enriched in plasmablasts) suggests lipid metabolism. ARPC1B/ARPC4 (Arp2/3) link to the cytoskeletal neighborhood. UBE2L3 (ubiquitin E2 conjugating enzyme) is involved in NF-κB and immune signaling. The glycolytic enzymes (LDHA, PGAM1, TALDO1) combined with mitochondrial components suggest a mixed aerobic glycolysis and mitochondrial program characteristic of activated plasmablasts. FABP5 enrichment points to lipid metabolic activity. I label this as glycolytic/metabolic reprogramming.
Genes
Most correlated modules
- Proteasome Activity · correlation 0.98
- RNA Splicing & Glycolysis · correlation 0.98
- Oxidative Stress Response · correlation 0.98
- Spliceosome snRNP Assembly · correlation 0.97
- Oxidative Phosphorylation · correlation 0.97
- Mitochondrial Respiration · correlation 0.97
- Actin Cytoskeletal Dynamics · correlation 0.97
- Chaperonin Protein Folding · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.