RNA Splicing Processing
Gene co-expression module in Plasma cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 27 genes have a known function matching the annotation |
Why this annotation
Moderate coherence, plasmablast-enriched, increased with inflammation. Hub genes include PLRG1 (pre-mRNA splicing), MFAP1 (splicing factor), U2SURP (U2 snRNP auxiliary factor), HTATSF1 (HIV TAT-SF1, RNA processing), XRN2 (5'-3' RNA exonuclease, transcription termination), FIP1L1 (mRNA 3' processing), GRSF1 (G-rich RNA sequence binding), SAP30 (Sin3A/HDAC complex), BRD7 (SWI/SNF/PBAF), ACTL6A (BAF chromatin remodeling), RFC2 (DNA replication factor C), BMS1 (ribosome biogenesis), NUP50 (nuclear pore). The dominant theme is RNA splicing and processing, with chromatin remodeling support. This is a neighbor to M13 (nuclear export/replication), together representing the transcriptional/post-transcriptional machinery of proliferating plasmablasts.
Genes
Most correlated modules
- Nuclear Transport Chromatin · correlation 0.97
- Housekeeping Mixed · correlation 0.96
- Chaperonin Protein Folding · correlation 0.96
- Mitochondrial Biogenesis · correlation 0.96
- Plasmablast Apoptosis · correlation 0.95
- Nuclear Export Replication · correlation 0.95
- Plasmablast Stress Activation · correlation 0.95
- Actin Cytoskeletal Dynamics · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.