Plasmablast Apoptosis
Gene co-expression module in Plasma cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 26 genes have a known function matching the annotation |
Why this annotation
Weak coherence module enriched in plasmablasts. Key genes include BAK1 and CASP3 (pro-apoptotic), SYK (B-cell receptor signaling kinase), PTPRC/CD45 (phosphatase regulating B-cell signaling), ADAM19 (metalloprotease involved in differentiation), ENTPD1/CD39 (ectonucleotidase), CTSC (cathepsin C, lysosomal protease), and SMARCC1 (SWI/SNF chromatin remodeling). The combination of apoptotic machinery with B-cell signaling components in plasmablasts suggests a plasmablast apoptosis/differentiation checkpoint program. No significant disease association. Weak coherence indicates a mixed program, but the apoptosis theme is dominant.
Genes
Most correlated modules
- Nuclear Export Replication · correlation 0.97
- Plasmablast Stress Activation · correlation 0.97
- Nuclear Transport Chromatin · correlation 0.96
- Plasmablast Proliferation · correlation 0.96
- RNA Splicing Processing · correlation 0.95
- Plasmablast Trafficking · correlation 0.95
- Polyamine Biosynthesis · correlation 0.95
- Ribosome Biogenesis · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.