Plasmablast Stress Activation
Gene co-expression module in Plasma cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 20 genes have a known function matching the annotation |
Why this annotation
Top hub genes EIF4G1 and EIF5B are translation initiation factors. G3BP1 is a stress granule nucleator. APOBEC3G and IFI16 are innate immune/antiviral sensors. SRP19 (signal recognition particle), NOP56 (rRNA processing), UBA1 (ubiquitin), STIP1 (HSP co-chaperone), and TCERG1 (transcription elongation) reflect broad cellular stress and activation. Module is upregulated with inflammation and enriched in plasmablasts. The combination of translation initiation machinery with stress granule and innate immune components suggests a plasmablast stress/activation state. Moderate coherence reflects the mixed nature of translation initiation and innate sensing programs.
Genes
Most correlated modules
- Nuclear Export Replication · correlation 0.97
- Nuclear Transport Chromatin · correlation 0.97
- Plasmablast Apoptosis · correlation 0.97
- Plasmablast Proliferation · correlation 0.96
- Polyamine Biosynthesis · correlation 0.95
- RNA Splicing Processing · correlation 0.95
- Ribosome Biogenesis · correlation 0.95
- Plasmablast Differentiation · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.