Plasmablast Proliferation
Gene co-expression module in Plasma cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 16 genes have a known function matching the annotation |
Why this annotation
Moderate coherence, plasmablast-enriched, significantly increased with inflammation. Hub genes include WAPL (cohesin release factor, mitosis), MAPRE1/EB1 (microtubule plus-end tracking, mitosis), PAFAH1B1/LIS1 (dynein regulator, mitosis), COPB1 (COPI vesicle trafficking), CSNK1A1 (casein kinase 1, cell cycle/Wnt), FDFT1 (cholesterol biosynthesis, membrane biogenesis), APOBEC3C (cytidine deaminase, somatic hypermutation), and ATAD3A (mitochondrial dynamics). The mitotic machinery genes (WAPL, MAPRE1, PAFAH1B1) combined with increased expression during inflammation suggest plasmablast proliferation. Neighbor modules M6 and M13 also show plasmablast proliferation programs, supporting this interpretation.
Genes
Most correlated modules
- Plasmablast Stress Activation · correlation 0.96
- Nuclear Transport Chromatin · correlation 0.96
- Nuclear Export Replication · correlation 0.96
- Plasmablast Apoptosis · correlation 0.96
- RNA Splicing Processing · correlation 0.95
- Plasmablast Trafficking · correlation 0.94
- COPI Vesicle Trafficking · correlation 0.94
- Polyamine Biosynthesis · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.