Plasmablast Differentiation
Gene co-expression module in Plasma cells
| Category | IgA production |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
All genes show weak module membership and the module has very low expression and pct positive. ETS1 and ARID3A are B-lineage transcription factors critical for plasmablast differentiation. SASH3 is a lymphocyte-specific SH3 scaffold protein. CLEC2D is an immune receptor ligand expressed on lymphocytes. MYH9 (non-muscle myosin IIA) is involved in B-cell activation and immune synapse formation. LARP7 regulates 7SK snRNP and transcriptional pausing. GTPBP4 and ABCE1 are involved in ribosome biogenesis/recycling. DHX9 is an RNA helicase involved in transcription and splicing. The module is poorly defined (all weak membership) but the plasmablast enrichment and TF content suggest a transitional B-cell to plasmablast differentiation program.
Genes
Most correlated modules
- Plasmablast Stress Activation · correlation 0.95
- Nuclear Export Replication · correlation 0.94
- Plasmablast Apoptosis · correlation 0.94
- Nuclear Transport Chromatin · correlation 0.93
- Plasmablast Proliferation · correlation 0.93
- Polyamine Biosynthesis · correlation 0.93
- COPI Vesicle Trafficking · correlation 0.92
- Ribosome Biogenesis · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.