Mitochondrial Biogenesis
Gene co-expression module in Plasma cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 3 of 7 genes have a known function matching the annotation |
Why this annotation
Hub genes include MRPL34 (mitochondrial ribosomal protein, large subunit) and UQCC2 (ubiquinol-cytochrome c reductase complex assembly factor 2, Complex III assembly), pointing to mitochondrial biogenesis and oxidative phosphorylation. PSMC3 (19S proteasome regulatory subunit) indicates proteasomal activity. SF3A3 and SNRNP27 are spliceosomal components. METTL26 is a methyltransferase. AP2M1 (clathrin adaptor mu2 subunit) is involved in endocytosis. The module is strongly coherent and significantly upregulated in inflammation (both UC and CD), suggesting increased mitochondrial and proteasomal activity in activated plasmablasts. The combination of mitoribosomal and Complex III assembly genes is the strongest signal. Neighbor M12 also has mitochondrial components (TOMM40, MRPL28), supporting a shared mitochondrial neighborhood.
Genes
Most correlated modules
- hnRNP RNA Processing · correlation 0.96
- Glycolytic Reprogramming · correlation 0.95
- Housekeeping Mixed · correlation 0.95
- Chaperonin Protein Folding · correlation 0.95
- OxPhos & Proteasome · correlation 0.95
- Ribosome Biogenesis · correlation 0.95
- Oxidative Stress Response · correlation 0.95
- Oxidative Phosphorylation · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.