Lipid Metabolite Transport
Gene co-expression module in Tuft cells
| Category | Cehmical sensing |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include PAQR7 (membrane progestin/lipid receptor), SLC27A3 (fatty acid transporter), SLCO4A1 (organic anion transporter), ABCC5 (ABC transporter), ADAMTS18 (extracellular matrix protease), CDH26 (cadherin adhesion), TRAK1 (mitochondrial trafficking adaptor), and FCGR2B (Fc receptor). All genes are strongly enriched in tuft cells. The module is upregulated in CD inflammation and reduced by treatment. The combination of lipid/metabolite transporters and membrane receptors suggests a lipid/metabolite sensing and transport program specific to tuft cells, consistent with their chemosensory identity.
Genes
Most correlated modules
- Tuft Chemosensory Transduction · correlation 0.90
- Tuft GPCR Signaling · correlation 0.90
- Actin Cytoskeletal Remodeling · correlation 0.89
- Cholinergic Tuft Signaling · correlation 0.74
- Tuft Cell Identity · correlation 0.71
- Tuft Secretory Processing · correlation 0.70
- Tuft Lipid Secretion · correlation 0.67
- Tuft Cell Identity · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.