Tuft Chemosensory Transduction
Gene co-expression module in Tuft cells
| Category | Cehmical sensing |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 15 genes have a known function matching the annotation |
Why this annotation
PLCB2 (phospholipase C beta 2) is the canonical downstream effector of tuft cell taste receptor signaling, generating IP3/DAG upon bitter/succinate detection. AVIL (advillin) is a tuft cell-specific actin-bundling protein and definitive tuft marker. GRK5 (G protein-coupled receptor kinase 5) desensitizes GPCRs, directly relevant to tuft chemosensory adaptation. KCNQ4 is a potassium channel involved in sensory cell excitability. INPP5D (SHIP1) is a phosphoinositide 5-phosphatase regulating PI3K signaling. PTPRJ is a receptor tyrosine phosphatase. CGNL1 (cingulin-like 1) is a tight junction-associated protein. ZMYND8 and ZNF638 are chromatin/transcriptional regulators. RNF213 is an E3 ubiquitin ligase. RUNX1 is a transcription factor. SKAP2 is a signaling adaptor. The module is the core tuft chemosensory transduction program, with the highest mean expression and pct positive in the batch.
Genes
Most correlated modules
- Lipid Metabolite Transport · correlation 0.90
- Tuft GPCR Signaling · correlation 0.87
- Tuft Lipid Secretion · correlation 0.85
- Actin Cytoskeletal Remodeling · correlation 0.85
- Tuft Secretory Processing · correlation 0.84
- Cholinergic Tuft Signaling · correlation 0.80
- Tuft Cell Identity · correlation 0.80
- Eicosanoid Inflammatory Modulation · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.