Tuft Lipid Secretion
Gene co-expression module in Tuft cells
| Category | Secretion |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
ALOX12B is a canonical tuft cell marker encoding arachidonate 12-lipoxygenase, central to lipid mediator (eicosanoid/leukotriene) biosynthesis in tuft cells. UNC13D mediates vesicle priming for secretion. GFI1B is a transcription factor associated with tuft/secretory lineage. GPR89B (highly tuft-enriched) is a Golgi pH regulator. BCAM, PDLIM5, PLEC are cytoskeletal/adhesion components. STK38 is a kinase. The module is upregulated in CD inflammation and suppressed by CD treatment, consistent with tuft cell expansion in IBD. The combination of ALOX12B-driven lipid mediator synthesis with secretory machinery (UNC13D) points to tuft cell lipid mediator secretion.
Genes
Most correlated modules
- Tuft Chemosensory Transduction · correlation 0.85
- Tuft Secretory Processing · correlation 0.80
- Tuft Cell Identity · correlation 0.80
- Cholinergic Tuft Signaling · correlation 0.80
- Tuft GPCR Signaling · correlation 0.79
- Actin Cytoskeletal Remodeling · correlation 0.75
- Eicosanoid Inflammatory Modulation · correlation 0.73
- Lipid Metabolite Transport · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.