Actin Cytoskeletal Remodeling
Gene co-expression module in Tuft cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
ACTN1 (alpha-actinin-1) cross-links actin filaments. COBL (cordon-bleu) nucleates actin polymerization and is critical for brush border/microvilli formation. MYO1E is a class I myosin involved in membrane-actin linkage. HIP1R links clathrin to actin. KALRN (kalirin) is a Rho GEF regulating actin cytoskeleton. FRY (furry) is highly tuft-enriched and regulates cytoskeletal polarity. MGLL (monoacylglycerol lipase) participates in lipid signaling. LRP5 is a Wnt co-receptor. SHB is a signaling adaptor. NPIPB5 is a nuclear pore-related gene. The dominant theme is actin cytoskeletal remodeling, consistent with tuft cell microvilli and morphological specialization. Upregulated in CD inflammation.
Genes
Most correlated modules
- Tuft Cell Identity · correlation 0.93
- Tuft GPCR Signaling · correlation 0.92
- Lipid Metabolite Transport · correlation 0.89
- Cholinergic Tuft Signaling · correlation 0.88
- Tuft Chemosensory Transduction · correlation 0.85
- Innate Immune Sensing · correlation 0.80
- Tuft Lipid Secretion · correlation 0.75
- Septin Cytoskeletal Organization · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.