Tuft Cell Identity
Gene co-expression module in Tuft cells
| Category | Cehmical sensing |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 12 genes have a known function matching the annotation |
Why this annotation
This module contains the canonical tuft cell gene signature: TRPM5 (taste transduction channel, defining tuft marker), SH2D6 and SH2D7 (tuft-specific SH2 domain proteins), PTGS1 (COX-1, prostaglandin synthesis hub in tuft cells), ALOX5 (5-lipoxygenase, leukotriene synthesis), ALOX5AP would be in M26 neighbor. FYB1, BMX, MATK are signaling kinases active in tuft chemosensory cascades. ITPR2 (IP3 receptor for calcium release), ATP2A3 (SERCA calcium pump), and PSTPIP2 (actin-binding) support calcium-dependent chemosensory signaling. Module is upregulated in CD inflammation and reduced by treatment, consistent with tuft cell expansion in IBD. This is the core tuft cell identity/chemosensory eicosanoid program.
Genes
Most correlated modules
- Tuft PI3K-Src Signaling · correlation 0.90
- RNA Splicing Regulation · correlation 0.82
- Tuft Chemosensory Signaling · correlation 0.71
- Tuft Microvilli Identity · correlation 0.70
- Tuft Chemosensory Receptor · correlation 0.70
- Tuft GPCR Signaling · correlation 0.67
- Lipid Metabolite Transport · correlation 0.66
- Tuft Chemosensory Transduction · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.