Tuft Cell Identity
Gene co-expression module in Tuft cells
| Category | Epithelial development |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 15 of 15 genes have a known function matching the annotation |
Why this annotation
CDHR2 (protocadherin LKC) is a definitive tuft cell apical marker essential for microvilli organization. NRG2 (neuregulin-2) is expressed by tuft cells for paracrine signaling. MGAM2 encodes maltase-glucoamylase, a brush border enzyme enriched in tuft cells. CLDN1 marks epithelial tight junctions. SMTN (smoothelin) and ARHGAP12/ARHGEF38/FARP2/RALGPS2 are cytoskeletal/Rho GTPase regulators supporting tuft cell morphology. MXD1 is a transcriptional repressor involved in differentiation. PCSK5 is a proprotein convertase. CYP3A5 is a metabolic enzyme. The module is highly tuft-enriched and upregulated in CD. CDHR2 anchors this as a tuft cell structural identity module.
Genes
Most correlated modules
- Actin Cytoskeletal Remodeling · correlation 0.93
- Cholinergic Tuft Signaling · correlation 0.87
- Tuft Lipid Secretion · correlation 0.80
- Tuft Chemosensory Transduction · correlation 0.80
- Tuft GPCR Signaling · correlation 0.78
- Innate Immune Sensing · correlation 0.76
- Heat Shock Stress Response · correlation 0.74
- Lipid Metabolite Transport · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.