Tuft GPCR Signaling
Gene co-expression module in Tuft cells
| Category | Cehmical sensing |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 12 genes have a known function matching the annotation |
Why this annotation
VAV1 is a Rho/Rac GEF classically associated with immune cell signaling but also expressed in tuft cells where it mediates chemosensory signal transduction. DOCK8 is a Rac GEF involved in immune and epithelial signaling. PIK3R5 encodes the PI3K p101 regulatory subunit, linking to phosphoinositide signaling downstream of GPCRs. PTPRT is a receptor tyrosine phosphatase highly enriched in tuft cells. GDPD5 is a glycerophosphodiester phosphodiesterase involved in lipid metabolism. ARHGEF1 is another Rho GEF. EPS8L3 is an actin/EGFR signaling protein enriched in tuft cells. RALGAPA2 regulates Ral GTPases. IGSF21 is an immunoglobulin superfamily member. TREH (trehalase) is a brush border enzyme. NPTX2 is a neuronal pentraxin. The module centers on Rho/PI3K/GPCR downstream signaling in tuft cells, consistent with chemosensory signal transduction.
Genes
Most correlated modules
- Actin Cytoskeletal Remodeling · correlation 0.92
- Lipid Metabolite Transport · correlation 0.90
- Cholinergic Tuft Signaling · correlation 0.89
- Tuft Chemosensory Transduction · correlation 0.87
- Tuft Lipid Secretion · correlation 0.79
- Tuft Cell Identity · correlation 0.78
- Innate Immune Sensing · correlation 0.74
- Tuft Cell Identity · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.