Cholinergic Tuft Signaling
Gene co-expression module in Tuft cells
| Category | Cehmical sensing |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 13 genes have a known function matching the annotation |
Why this annotation
CHAT (choline acetyltransferase) is the defining enzyme for acetylcholine biosynthesis and is the canonical marker of intestinal tuft cells, which synthesize and release acetylcholine to activate ILC2s. LIMCH1 (LIM and calponin homology domains) supports cytoskeletal organization. ARHGAP4 and CHN2 (chimerin) are Rho GTPase regulators. KLK13 (kallikrein-13) is a serine protease enriched in tuft cells. DAPK1 regulates apoptosis and cytoskeletal dynamics. FES is a non-receptor tyrosine kinase. PVR (CD155) mediates immune interactions. PEAK1, MINK1 are kinases. AP1G2 is involved in vesicle trafficking. PCM1 is a centrosomal protein. The module is significantly upregulated in CD and suppressed by treatment, consistent with cholinergic tuft cell expansion in IBD.
Genes
Most correlated modules
- Tuft GPCR Signaling · correlation 0.89
- Actin Cytoskeletal Remodeling · correlation 0.88
- Tuft Cell Identity · correlation 0.87
- Tuft Chemosensory Transduction · correlation 0.80
- Tuft Lipid Secretion · correlation 0.80
- Innate Immune Sensing · correlation 0.76
- Lipid Metabolite Transport · correlation 0.74
- Septin Cytoskeletal Organization · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.