Tuft Surface Identity
Gene co-expression module in Tuft cells
| Category | migration & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include CEACAM1 (cell adhesion/immune modulation), HEPACAM2 (cell adhesion molecule), CD300LF (inhibitory immune receptor), CLIC5 (chloride channel enriched at brush border), MYO1B (brush border myosin), CDCP1 (membrane protease substrate), and MSI2 (RNA-binding). All genes show strong tuft enrichment. The module reflects tuft cell membrane identity with brush border/apical surface organization and cell adhesion character. ERO1B suggests ER-linked membrane protein processing. FBXO32 (atrogin-1) links to protein turnover. Upregulated in CD inflammation and reduced by treatment, consistent with a tuft cell surface identity program modulated by disease.
Genes
Most correlated modules
- Tuft Calcium Signaling · correlation 0.99
- Tuft Chemosensory Receptor · correlation 0.97
- IFN-Tuft Activation · correlation 0.97
- Tuft Cell Identity · correlation 0.97
- Tuft Progenitor State · correlation 0.96
- Tuft Microvilli Identity · correlation 0.96
- Antimicrobial Defense · correlation 0.95
- Tuft Chemosensory Signaling · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.