Tuft Cell Identity
Gene co-expression module in Tuft cells
| Category | Epithelial development |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 10 genes have a known function matching the annotation |
Why this annotation
POU2F3 is the master transcription factor for tuft cell fate specification — its presence as a high-PageRank hub gene makes this the core tuft identity module. KIT (c-Kit/CD117) is a receptor tyrosine kinase co-expressed with POU2F3 in tuft cells and used as a tuft cell marker. PROX1 is a transcription factor expressed in tuft/lymphatic progenitors. ALMS1 is associated with cilia/basal body function relevant to tuft microvilli. UTRN (utrophin) and MACF1 are cytoskeletal scaffolding proteins supporting tuft cell morphology. COL9A3 is a collagen expressed in tuft cell niches. RICTOR (mTORC2 component) regulates tuft cell metabolism. TET2 (DNA demethylase) and CMIP regulate transcriptional programs. This module defines the core tuft cell transcriptional identity program.
Genes
Most correlated modules
- Tuft Surface Identity · correlation 0.97
- IFN-Tuft Activation · correlation 0.95
- Tuft Calcium Signaling · correlation 0.95
- Tuft Chemosensory Receptor · correlation 0.94
- Tuft Microvilli Identity · correlation 0.92
- Tuft Progenitor State · correlation 0.92
- Antimicrobial Defense · correlation 0.91
- RNA Splicing Regulation · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.