Tuft Progenitor State
Gene co-expression module in Tuft cells
| Category | Epithelial development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
SMOC1 shows extreme tuft enrichment (22.3x) and is a secreted extracellular matrix modulator associated with progenitor niches. TFCP2L1 is a transcription factor marking stem/progenitor states in intestinal epithelium. SRC tyrosine kinase is a key signaling hub downstream of growth factor receptors and is expressed in tuft cells; notably M66 contains CSK (the SRC inhibitory kinase), suggesting these two modules are functionally linked. GDA (guanine deaminase) is highly tuft-enriched. CSMD1 (complement control domain protein) is enriched in tuft. THBS1 (thrombospondin-1) is an ECM glycoprotein with roles in cell-matrix signaling. USP34 is a deubiquitinase. PAPSS2 is involved in sulfation. This module reflects a tuft progenitor/ECM-signaling state.
Genes
Most correlated modules
- Tuft Calcium Signaling · correlation 0.98
- IFN-Tuft Activation · correlation 0.97
- Tuft Surface Identity · correlation 0.96
- Antimicrobial Defense · correlation 0.94
- Pre-tuft Progenitor State · correlation 0.93
- Tuft Cell Identity · correlation 0.92
- Tuft Microvilli Identity · correlation 0.91
- Intestinal Progenitor Differentiation · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.