Tuft Chemosensory Signaling
Gene co-expression module in Tuft cells
| Category | Cehmical sensing |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 17 genes have a known function matching the annotation |
Why this annotation
HPGDS (hematopoietic prostaglandin D synthase) is the canonical tuft cell marker and hub gene here. AOC1 (diamine oxidase, histamine/polyamine catabolism), IL13RA1 (IL-13 receptor alpha 1, type 2 immune sensing), AZGP1 (lipid mobilization), PLEKHB1, and TMEM176A/B (ion channels involved in chemosensory signaling) define the tuft cell chemosensory and type 2 immune signaling identity. IFI6 and HLA genes suggest an interferon/antigen-presentation overlay in inflamed CD tissue, consistent with the strong CD inflammation upregulation. PSAP and GSN support lipid/actin biology in tuft cells.
Genes
Most correlated modules
- Tuft Chemosensory Receptor · correlation 0.90
- Tuft Surface Identity · correlation 0.89
- Tuft Cell Identity · correlation 0.87
- Antimicrobial Defense · correlation 0.85
- Tuft PI3K-Src Signaling · correlation 0.84
- Tuft Calcium Signaling · correlation 0.82
- IFN-Tuft Activation · correlation 0.82
- Tuft Microvilli Identity · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.