Tuft Chemosensory Receptor
Gene co-expression module in Tuft cells
| Category | Cehmical sensing |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
TAS1R3 (taste receptor type 1, member 3) is a canonical tuft cell chemosensory receptor mediating sweet/umami taste sensing and luminal nutrient detection. CSK (C-terminal Src kinase) phosphorylates and inhibits SRC-family kinases, directly linking to M79 (which contains SRC), suggesting these neighbor modules represent complementary arms of tuft kinase signaling. PCLO (piccolo) is a presynaptic active zone scaffold expressed in chemosensory/neuroendocrine cells. CLRN3 (clarin-3) is expressed in sensory cells. MAP7 stabilizes microtubules in polarized epithelial cells. IGSF3 is a cell adhesion molecule. CAPN12 (calpain-12) is expressed in epithelial brush border. TGOLN2 marks trans-Golgi network. The module is anchored by TAS1R3 and reflects tuft chemosensory receptor signaling.
Genes
Most correlated modules
- Tuft Surface Identity · correlation 0.97
- Tuft Calcium Signaling · correlation 0.96
- Tuft Cell Identity · correlation 0.94
- Tuft Microvilli Identity · correlation 0.94
- IFN-Tuft Activation · correlation 0.93
- Tuft PI3K-Src Signaling · correlation 0.91
- Tuft Chemosensory Signaling · correlation 0.90
- Antimicrobial Defense · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.