IFN-Tuft Activation
Gene co-expression module in Tuft cells
| Category | Inflamation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
VIPR1 (vasoactive intestinal peptide receptor 1) is a well-established tuft cell marker mediating neuropeptide sensing. FCGR2A (Fc gamma receptor IIA) is an immune receptor expressed on tuft cells in inflammatory contexts. STAT1 is a central IFN signaling transcription factor, upregulated in inflammation. CDKN1A (p21/CIP1) is an IFN/STAT1 target and cell cycle inhibitor induced by inflammatory stress. NAV2 (neuron navigator 2) supports neuronal-like tuft identity. ST6GALNAC3 (sialyltransferase) modifies cell surface glycans. PLEKHG7 is a Rho GEF. The module combines tuft neuroendocrine identity (VIPR1, NAV2) with IFN/inflammatory response (STAT1, CDKN1A, FCGR2A), consistent with tuft cell activation in IBD.
Genes
Most correlated modules
- Tuft Calcium Signaling · correlation 0.98
- Tuft Progenitor State · correlation 0.97
- Antimicrobial Defense · correlation 0.97
- Tuft Surface Identity · correlation 0.97
- Tuft Cell Identity · correlation 0.95
- Pre-tuft Progenitor State · correlation 0.93
- Tuft Chemosensory Receptor · correlation 0.93
- Intestinal Progenitor Differentiation · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.