Antimicrobial Defense
Gene co-expression module in Tuft cells
| Category | Inflamation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 17 genes have a known function matching the annotation |
Why this annotation
Top hub genes include CAMP (cathelicidin, broad-spectrum antimicrobial peptide), LYZ (lysozyme, bacterial cell wall lysis), DEFB1 (defensin beta-1, antimicrobial), and CD14 (LPS co-receptor, innate immune pattern recognition). RGS13 is expressed in tuft/mast cells and modulates G-protein signaling downstream of chemosensory receptors. NQO1 (NAD(P)H quinone oxidoreductase) provides oxidative stress protection. USP18 is an ISG15 deubiquitinase involved in interferon signaling. LGALS3BP is a galectin-3 binding protein with innate immune roles. CCDC28B is linked to cilia/BBSome. This module represents an innate antimicrobial defense program in tuft cells, consistent with their known role in mucosal immunity.
Genes
Most correlated modules
- IFN-Tuft Activation · correlation 0.97
- Tuft Surface Identity · correlation 0.95
- Tuft Calcium Signaling · correlation 0.95
- Tuft Progenitor State · correlation 0.94
- Pre-tuft Progenitor State · correlation 0.94
- Intestinal Progenitor Differentiation · correlation 0.93
- Sulfur Redox Detox · correlation 0.92
- Mitochondrial OxPhos/TCA · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.