Tuft Calcium Signaling
Gene co-expression module in Tuft cells
| Category | Cehmical sensing |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 11 genes have a known function matching the annotation |
Why this annotation
DCLK2 (doublecortin-like kinase 2) is a canonical tuft cell marker and hub gene. CAMK2D (calcium/calmodulin-dependent kinase II delta) and TANC2 (postsynaptic density scaffold) reflect the neuronal-like calcium signaling characteristic of tuft cells. KIF1B (kinesin motor for vesicle transport), SYNE3 (LINC complex nuclear envelope), TBC1D2B (Rab GTPase activating), and RIMKLB (metabolic enzyme) support a tuft-specific intracellular signaling/transport program. EHF is an epithelial ETS transcription factor. KLK11 (kallikrein serine protease) is enriched in tuft. The module captures tuft-specific calcium-dependent kinase signaling, consistent with chemosensory signal transduction.
Genes
Most correlated modules
- Tuft Surface Identity · correlation 0.99
- Tuft Progenitor State · correlation 0.98
- IFN-Tuft Activation · correlation 0.98
- Tuft Chemosensory Receptor · correlation 0.96
- Tuft Cell Identity · correlation 0.95
- Antimicrobial Defense · correlation 0.95
- Tuft Microvilli Identity · correlation 0.94
- Pre-tuft Progenitor State · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.