Pre-tuft Progenitor Metabolism
Gene co-expression module in Tuft cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 8 genes have a known function matching the annotation |
Why this annotation
All 8 genes are strongly enriched in pre_tuft cells (~3.3-4.5x). Hub genes include COA3 (cytochrome c oxidase assembly factor), NDUFV2 (NADH:ubiquinone oxidoreductase core subunit, Complex I), PGAM1 (phosphoglycerate mutase, glycolysis), RAB25 (vesicle trafficking GTPase), CLTA (clathrin light chain A, endocytosis), DSTN (destrin/actin dynamics), ADI1 (acireductone dioxygenase), and S100A16 (calcium-binding protein). The presence of mitochondrial complex I subunit (NDUFV2) alongside glycolytic (PGAM1) and vesicular trafficking genes suggests a mixed metabolic/housekeeping program in pre-tuft progenitor cells. The disease response shows significant downregulation in CD inflammation and recovery with CD treatment, consistent with a pre-tuft progenitor state program. The dominant signal is mitochondrial/metabolic housekeeping enriched in pre-tuft cells.
Genes
Most correlated modules
- Pre-tuft Mitochondrial Metabolic · correlation 0.98
- Mitotic Spindle Assembly · correlation 0.97
- Translation Initiation · correlation 0.97
- ATP Synthase OxPhos · correlation 0.97
- Mitochondrial Housekeeping · correlation 0.96
- Mitochondrial OxPhos Complex I · correlation 0.96
- Glycolytic TCA Metabolism · correlation 0.96
- Protein Folding Proteostasis · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.