Mitochondrial OxPhos Complex I
Gene co-expression module in Tuft cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
All genes are enriched in pre_tuft cells (~3.1-4.3x). Hub genes include TSPO (translocator protein, mitochondrial outer membrane, involved in cholesterol import and mitochondrial function), NDUFB11 and NDUFB9 (NADH:ubiquinone oxidoreductase subunits, Complex I), ATP5PD (ATP synthase peripheral stalk subunit, Complex V), MRPL14 (mitochondrial ribosomal protein), NEDD8 (neddylation pathway, protein modification), POLR2I (RNA polymerase II subunit), and SEM1 (26S proteasome regulatory subunit). The module is dominated by mitochondrial OxPhos components (Complex I, ATP synthase) and mitochondrial ribosome, with TSPO as a key hub. This is a mitochondrial biogenesis/OxPhos module in pre-tuft progenitors. Neighbor context: closely related to M10, M22, M31, M47, M46 which all share NDUF subunits and pre_tuft enrichment.
Genes
Most correlated modules
- Translation Initiation · correlation 0.98
- Pre-tuft Mitochondrial Metabolic · correlation 0.98
- Mitochondrial Translation · correlation 0.98
- Respiratory Chain OxPhos · correlation 0.98
- Mitochondrial OxPhos Assembly · correlation 0.98
- ATP Synthase OxPhos · correlation 0.97
- Mitochondrial Housekeeping · correlation 0.97
- Mixed OxPhos Secretory · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.