Mitotic Spindle Assembly
Gene co-expression module in Tuft cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
MZT2A and MZT2B encode mitotic spindle organizing proteins (γ-TuRC components for microtubule nucleation). NPM1 (nucleophosmin) is a key ribosome biogenesis and cell cycle regulator enriched in proliferating cells. BANF1 regulates nuclear envelope reassembly post-mitosis. EIF5A is a translation elongation factor. LSM2 and SNU13 are spliceosomal snRNP components. MRPS33 is a mitochondrial ribosomal protein. CENPX is a centromere/kinetochore protein active in mitosis. MT2A and PRDX5 reflect redox homeostasis. The module combines mitotic spindle organization with RNA splicing and ribosome biogenesis, pointing to an actively proliferating pre_tuft progenitor program. MZT2A/B and CENPX specifically anchor this to mitotic activity.
Genes
Most correlated modules
- Precursor Cell Cycle · correlation 0.99
- Translation Initiation · correlation 0.98
- Progenitor Cell Proliferation · correlation 0.98
- Glycolytic TCA Metabolism · correlation 0.98
- Ribosome Biogenesis · correlation 0.98
- Epithelial Progenitor Differentiation · correlation 0.97
- Metallothionein Stress Response · correlation 0.97
- Mitochondrial OxPhos Assembly · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.