Translation Initiation
Gene co-expression module in Tuft cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes EIF3H and EIF3L are core subunits of the eIF3 translation initiation complex. BTF3 encodes the nascent polypeptide-associated complex beta subunit involved in translation. NHP2 is a component of H/ACA snoRNPs involved in ribosome biogenesis. SNRPB is a core snRNP protein for pre-mRNA splicing. SLC25A5 (ANT2) provides ATP for biosynthetic processes. PSMA4 is a proteasome subunit. S100A10 is a calcium-binding protein. The module is dominated by translation initiation and RNA processing machinery, consistent with high biosynthetic activity in pre_tuft progenitors. Neighbor context: complements M55 (also RNA processing) and M27 (ribosome biogenesis).
Genes
Most correlated modules
- Mitotic Spindle Assembly · correlation 0.98
- Precursor Cell Cycle · correlation 0.98
- Mitochondrial OxPhos Complex I · correlation 0.98
- Progenitor Cell Proliferation · correlation 0.97
- Mitochondrial OxPhos Assembly · correlation 0.97
- Ribosome Biogenesis · correlation 0.97
- Glycolytic TCA Metabolism · correlation 0.97
- Metallothionein Stress Response · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.