Protein Folding Proteostasis
Gene co-expression module in Tuft cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
CCT7 encodes a subunit of the TRiC/CCT chaperonin complex essential for protein folding. PSMB5 is the catalytic beta-5 subunit of the 20S proteasome (chymotryptic activity). SUMO1 mediates SUMOylation for protein quality control and nuclear transport. RANBP1 regulates RanGTPase for nuclear-cytoplasmic transport. ETHE1 is a mitochondrial persulfide dioxygenase involved in sulfur metabolism/proteostasis. CLNS1A, LSM6 (splicing), ERH (RNA processing), SPCS1 (signal peptidase), NDUFAF8 (Complex I assembly), and SIVA1 (apoptosis) are peripheral. The core program is protein folding and proteostasis (chaperonin + proteasome) in pre_tuft progenitors, consistent with high protein turnover during differentiation.
Genes
Most correlated modules
- ATP Synthase OxPhos · correlation 0.98
- Mitochondrial Biogenesis · correlation 0.97
- Glycolytic TCA Metabolism · correlation 0.97
- Prostaglandin Biosynthesis · correlation 0.96
- Mitotic Spindle Assembly · correlation 0.96
- Pre-tuft Progenitor Metabolism · correlation 0.96
- ER Membrane Biogenesis · correlation 0.96
- RNA Splicing Translation · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.