Glycolytic TCA Metabolism
Gene co-expression module in Tuft cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
All genes strongly enriched in pre_tuft. ENO1 and GPI are glycolytic enzymes; SUCLG2 encodes a TCA cycle subunit; ACAA2 is involved in fatty acid beta-oxidation; GPX2 is an antioxidant glutathione peroxidase; CCNG1 is a p53-regulated cyclin. HMGA1 is a chromatin architectural protein active in progenitors. The module reflects a glycolytic/TCA metabolic program in pre-tuft progenitors with antioxidant defense.
Genes
Most correlated modules
- ATP Synthase OxPhos · correlation 0.98
- Prostaglandin Biosynthesis · correlation 0.98
- Mitotic Spindle Assembly · correlation 0.98
- Precursor Cell Cycle · correlation 0.98
- Pre-tuft Biosynthetic · correlation 0.98
- Secretory Progenitor Commitment · correlation 0.98
- Translation Initiation · correlation 0.97
- Metallothionein Stress Response · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.