Pre-tuft Mitochondrial Metabolic
Gene co-expression module in Tuft cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 10 genes have a known function matching the annotation |
Why this annotation
All 10 genes are enriched in pre_tuft cells (~2.8-4.8x). Hub genes include SSB (Sjogren syndrome antigen B / La protein, RNA binding), LDHB (lactate dehydrogenase B, glycolysis/gluconeogenesis), NDUFA5 (Complex I subunit), TMED10 (transmembrane emp24 domain protein, ER-Golgi trafficking), NUCKS1 (nuclear casein kinase substrate, chromatin remodeling), SRP9 (signal recognition particle 9kDa subunit, co-translational targeting), ANP32B (acidic nuclear phosphoprotein, chromatin regulation), TUFM (mitochondrial translation elongation factor), VDAC1 (voltage-dependent anion channel 1, mitochondrial outer membrane), PDCD6 (programmed cell death 6/ALG-2, calcium-binding). The module mixes mitochondrial (NDUFA5, TUFM, VDAC1), ER/secretory (TMED10, SRP9), and nuclear/RNA-binding (SSB, NUCKS1, ANP32B) components. The mitochondrial and metabolic genes dominate, with LDHB indicating metabolic activity. This is a mixed pre-tuft metabolic/mitochondrial module.
Genes
Most correlated modules
- Pre-tuft Progenitor Metabolism · correlation 0.98
- Mitochondrial OxPhos Complex I · correlation 0.98
- ATP Synthase OxPhos · correlation 0.97
- Translation Initiation · correlation 0.96
- Mixed OxPhos Secretory · correlation 0.96
- ER Membrane Biogenesis · correlation 0.96
- Mitochondrial OxPhos Assembly · correlation 0.96
- Glycolytic TCA Metabolism · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.