Precursor Cell Cycle
Gene co-expression module in Tuft cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
Hub gene CKS1B is a canonical cell cycle regulator (S/G2 phase). PHB2 and C1QBP are mitochondrial inner membrane/ribosome assembly factors active in proliferating cells. ATP5MC1 is an ATP synthase subunit supporting high energy demand. MT1E/ADIRF reflect stress-adaptive responses in precursor cells. TMED3 supports vesicle trafficking. All genes are strongly enriched in pre_tuft cells, consistent with a proliferating tuft precursor state. The combination of cell cycle (CKS1B) with mitochondrial bioenergetics (PHB2, C1QBP, ATP5MC1) is characteristic of actively cycling progenitors.
Genes
Most correlated modules
- Metallothionein Stress Response · correlation 0.99
- Epithelial Progenitor Differentiation · correlation 0.99
- Mitotic Spindle Assembly · correlation 0.99
- Secretory Progenitor Commitment · correlation 0.99
- Progenitor S-phase · correlation 0.98
- Translation Initiation · correlation 0.98
- Ribosome Biogenesis · correlation 0.98
- Prostaglandin Biosynthesis · correlation 0.98
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.