Prostaglandin Biosynthesis
Gene co-expression module in Tuft cells
| Category | Cehmical sensing |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
Extremely high pre_tuft enrichment (up to 34x). AKR1C3 is a key enzyme in prostaglandin and androgen metabolism, directly relevant to tuft cell identity (tuft cells produce prostaglandins). SLPI is an anti-inflammatory serine protease inhibitor. BCL2L15 regulates apoptosis during differentiation. MT1H (metallothionein) reflects metal/oxidative stress response. PAICS and GNPNAT1 support purine and hexosamine biosynthesis. SUCLG1 is TCA cycle. UNG supports DNA repair. IQGAP2 is a scaffold involved in cell polarity. This module captures prostaglandin biosynthetic capacity and differentiation-associated stress responses in pre-tuft cells.
Genes
Most correlated modules
- Progenitor S-phase · correlation 0.99
- Secretory Progenitor Commitment · correlation 0.99
- Precursor Cell Cycle · correlation 0.98
- Metallothionein Stress Response · correlation 0.98
- Glycolytic TCA Metabolism · correlation 0.98
- Pre-tuft Biosynthetic · correlation 0.98
- Mitochondrial Biogenesis · correlation 0.98
- Pre-tuft WNT Secretion · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.