Heat Shock Stress Response
Gene co-expression module in Tuft cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include GEM (GTP-binding protein overexpressed in skeletal muscle, also an immediate-early/stress-induced RAS-like GTPase), PWWP3A (chromatin-associated PWWP domain), SEPTIN7 (septin cytoskeletal, neighbor to M20's SEPTIN2/9), GALNT4 (O-GalNAc glycosyltransferase, mucin-type glycosylation), RNASEK (RNase kappa, antiviral), TSPYL2 (nucleosome assembly/chromatin), TJP2 (tight junction protein ZO-2, epithelial barrier), MED29 (Mediator complex subunit, transcriptional coactivation), DLL1 (Notch ligand, neighbor to M12's DLL4), HSPA6 (heat shock protein 70 family, strong stress marker). GEM and HSPA6 are classic stress/heat shock response genes. DLL1 connects to Notch signaling. The module appears to represent a stress-activated program with Notch ligand upregulation and tight junction remodeling, potentially reflecting tuft cell stress-induced barrier and Notch signaling.
Genes
Most correlated modules
- Septin Cytoskeletal Organization · correlation 0.77
- Heat Shock Response · correlation 0.76
- Tuft Cell Identity · correlation 0.74
- Innate Immune Sensing · correlation 0.65
- Actin Cytoskeletal Remodeling · correlation 0.54
- Cholinergic Tuft Signaling · correlation 0.50
- Stress Transcriptional Response · correlation 0.39
- Tuft Lipid Secretion · correlation 0.35
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.