Septin Cytoskeletal Organization
Gene co-expression module in Tuft cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
Top hub genes are SEPTIN2 and SEPTIN9, members of the septin GTPase family that form cytoskeletal filaments involved in cell division, membrane compartmentalization, and vesicle trafficking. CALML4 (calmodulin-like, cytoskeletal regulation), TRAPPC5 (TRAPP vesicle tethering complex), DOP1B (Dopey family, Golgi/vesicle trafficking), ATP6V0C (V-ATPase subunit, vesicle acidification), CRIP1 (LIM domain cytoskeletal), ANKHD1 (ankyrin repeat scaffold), BNIP5 (BCL2-interacting, extremely high tuft enrichment at 114x), POLD4 (DNA polymerase delta subunit), ALDOA (glycolysis/cytoskeletal moonlighting). The septin-dominated module with vesicle trafficking components suggests cytoskeletal organization and membrane compartmentalization. BNIP5's extreme tuft enrichment is notable.
Genes
Most correlated modules
- Innate Immune Sensing · correlation 0.93
- Heat Shock Stress Response · correlation 0.77
- Tuft Cell Identity · correlation 0.70
- Cholinergic Tuft Signaling · correlation 0.64
- Actin Cytoskeletal Remodeling · correlation 0.63
- Tuft Lipid Secretion · correlation 0.58
- Tuft GPCR Signaling · correlation 0.54
- Stress Transcriptional Response · correlation 0.47
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.