Innate Immune Sensing
Gene co-expression module in Tuft cells
| Category | Inflamation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include LIME1 (Lck-interacting adaptor in immune signaling), TLR9 (innate immune receptor for bacterial/viral DNA), CAPN3 (calpain protease), PRXL2A (peroxiredoxin-like antioxidant), TLE5 (transcriptional repressor), RELCH (Rab11-FIP/vesicle trafficking), SRCAP (chromatin remodeling ATPase), HMX3 (homeobox transcription factor), MYO15B (unconventional myosin), and ITPRID1. Extremely high tuft enrichment (up to 48x). TLR9 and LIME1 suggest innate immune/pathogen sensing. The module has very low expression and pct positive, suggesting a rare subpopulation or low-level program. The combination of immune sensing (TLR9, LIME1) with chromatin regulation (SRCAP) and transcriptional repression (TLE5) may reflect a tuft-specific innate immune sensing state.
Genes
Most correlated modules
- Septin Cytoskeletal Organization · correlation 0.93
- Actin Cytoskeletal Remodeling · correlation 0.80
- Cholinergic Tuft Signaling · correlation 0.76
- Tuft Cell Identity · correlation 0.76
- Tuft GPCR Signaling · correlation 0.74
- Heat Shock Stress Response · correlation 0.65
- Tuft Lipid Secretion · correlation 0.60
- Lipid Metabolite Transport · correlation 0.53
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.