Mitochondrial Biogenesis
Gene co-expression module in Tuft cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes NDUFAB1, DMAC1, NDUFA12, CLPP, BOLA3 are all directly involved in mitochondrial Complex I assembly and mitochondrial iron-sulfur cluster biogenesis. CLPP is the mitochondrial matrix protease essential for mitochondrial protein quality control. NAMPT drives NAD+ biosynthesis feeding OxPhos. BLVRB is a redox enzyme. LSM5 and PSMA5 are housekeeping but the dominant theme is mitochondrial biogenesis in pre_tuft progenitors. All genes enriched in pre_tuft (4-8x), consistent with metabolic reprogramming during tuft cell differentiation.
Genes
Most correlated modules
- Pre-tuft Biosynthetic · correlation 0.98
- Prostaglandin Biosynthesis · correlation 0.98
- Mitochondrial Translation · correlation 0.98
- RNA Splicing Translation · correlation 0.97
- Progenitor S-phase · correlation 0.97
- Protein Folding Proteostasis · correlation 0.97
- Glycolytic TCA Metabolism · correlation 0.97
- Precursor Cell Cycle · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.