Mitochondrial OxPhos Assembly
Gene co-expression module in Tuft cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
NDUFS5 (Complex I subunit) and COA4 (Complex IV assembly factor) anchor this module to mitochondrial respiratory chain. NSA2 and SNRPD2 contribute ribosome biogenesis and splicing. QTRT1 (tRNA queuosine modification) and SUB1 (transcription coactivator) are general housekeeping. RNF7 (CRL E3 ligase) and SLC35A3 (Golgi UDP-GlcNAc transporter) are peripheral. The module is a mixed housekeeping program in pre_tuft cells, but the mitochondrial respiratory chain assembly genes are the most coherent biological thread connecting it to neighbor modules M56 and M44.
Genes
Most correlated modules
- Mitochondrial OxPhos Complex I · correlation 0.98
- Translation Initiation · correlation 0.97
- Mitotic Spindle Assembly · correlation 0.97
- Mitochondrial Translation · correlation 0.97
- Mitochondrial Biogenesis · correlation 0.97
- ATP Synthase OxPhos · correlation 0.97
- Progenitor Metabolic Reprogramming · correlation 0.96
- Glycolytic TCA Metabolism · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.